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Open Access
Peer-reviewed
Research Article
Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure
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Sakurako Tanida,
Roles Formal analysis, Investigation, Software, Visualization, Writing – original draft
Affiliations Universal Biology Institute, Graduate School of Science, The University of Tokyo, Tokyo, Japan, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan, Department of Aeronautics and Astronautics, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
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Kana Fuji,
Roles Validation, Writing – review & editing
Affiliation Universal Biology Institute, Graduate School of Science, The University of Tokyo, Tokyo, Japan
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Linjie Lu,
Roles Visualization, Writing – review & editing
Affiliations University of Strasbourg, Illkirch, France, French National Centre for Scientific Research (CNRS), University of Strasbourg, Illkirch, France, French National Institute of Health and Medical Research (INSERM), University of Strasbourg, Illkirch, France, Institute of Genetics and of Molecular and Cellular Biology, University of Strasbourg, Illkirch, France
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Tristan Guyomar,
Roles Visualization, Writing – review & editing
Affiliations University of Strasbourg, Illkirch, France, French National Centre for Scientific Research (CNRS), University of Strasbourg, Illkirch, France, French National Institute of Health and Medical Research (INSERM), University of Strasbourg, Illkirch, France, Institute of Genetics and of Molecular and Cellular Biology, University of Strasbourg, Illkirch, France
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Byung Ho Lee,
Roles Visualization, Writing – review & editing
Affiliation Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
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Alf Honigmann,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliations Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany, Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany
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Anne Grapin-Botton,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliations Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany
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Daniel Riveline,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
Affiliations University of Strasbourg, Illkirch, France, French National Centre for Scientific Research (CNRS), University of Strasbourg, Illkirch, France, French National Institute of Health and Medical Research (INSERM), University of Strasbourg, Illkirch, France, Institute of Genetics and of Molecular and Cellular Biology, University of Strasbourg, Illkirch, France
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Tetsuya Hiraiwa ,
Roles Methodology, Writing – original draft
* E-mail: thiraiwa@as.edu.tw (TH); nonomura.makiko@nihon-u.ac.jp (MN); sano@phys.s.u-tokyo.ac.jp (MS)
Affiliations Universal Biology Institute, Graduate School of Science, The University of Tokyo, Tokyo, Japan, Mechanobiology Institute, National University of Singapore, Singapore, Singapore, Institute of Physics, Academia Sinica, Taipei, Taiwan
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Makiko Nonomura ,
Roles Investigation, Methodology, Visualization, Writing – review & editing
* E-mail: thiraiwa@as.edu.tw (TH); nonomura.makiko@nihon-u.ac.jp (MN); sano@phys.s.u-tokyo.ac.jp (MS)
Affiliation Department of Mathematical Information Engineering, College of Industrial Technology, Nihon University, Chiba, Japan
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Masaki Sano
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft
* E-mail: thiraiwa@as.edu.tw (TH); nonomura.makiko@nihon-u.ac.jp (MN); sano@phys.s.u-tokyo.ac.jp (MS)
Affiliations Universal Biology Institute, Graduate School of Science, The University of Tokyo, Tokyo, Japan, Institute of Natural Sciences, School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China
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Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure
- Sakurako Tanida,
- Kana Fuji,
- Linjie Lu,
- Tristan Guyomar,
- Byung Ho Lee,
- Alf Honigmann,
- Anne Grapin-Botton,
- Daniel Riveline,
- Tetsuya Hiraiwa,
- Makiko Nonomura
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- Published: August 18, 2025
- https://doi.org/10.1371/journal.pcbi.1012090