Synergistic epistasis among cancer drivers can rescue early tumors from the accumulation of deleterious passengers

• Carla Alejandre ,

  Contributed equally to this work with: Carla Alejandre, Jorge Calle-Espinosa

  Roles Investigation, Software, Writing – original draft, Writing – review & editing

  Affiliations Centro de Astrobiología (CAB) CSIC-INTA, Torrejón de Ardoz, Madrid, Spain, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)—Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain

  https://orcid.org/0000-0003-2141-618X

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• Jorge Calle-Espinosa ,

  Contributed equally to this work with: Carla Alejandre, Jorge Calle-Espinosa

  Roles Conceptualization, Formal analysis, Investigation, Software, Writing – original draft, Writing – review & editing

  Affiliation Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)—Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain

  https://orcid.org/0000-0003-2090-2768

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• Jaime Iranzo

  Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jaime.iranzo@cab.inta-csic.es

  Affiliations Centro de Astrobiología (CAB) CSIC-INTA, Torrejón de Ardoz, Madrid, Spain, Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)—Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain, Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Zaragoza, Spain

  https://orcid.org/0000-0002-4538-7726

  ⨯