Validity conditions of approximations for a target-mediated drug disposition model: A novel first-order approximation and its comparison to other approximations

• Jong Hyuk Byun,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Mathematics and Institute of Mathematical Science, Pusan National University, Busan, Republic of Korea, Institute for Future Earth, Pusan National University, Busan, Republic of Korea

  https://orcid.org/0000-0001-6334-8176

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• Hye Seon Jeon ,

  Roles Data curation, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hyeseon0128@o.cnu.ac.kr (HSJ); hyyun@cnu.ac.kr (H-yY); jaekkim@kaist.ac.kr (JKK)

  Affiliation College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea

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• Hwi-yeol Yun ,

  Roles Data curation, Funding acquisition, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hyeseon0128@o.cnu.ac.kr (HSJ); hyyun@cnu.ac.kr (H-yY); jaekkim@kaist.ac.kr (JKK)

  Affiliations College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea, Department of Bio-AI Convergence, Chungnam National University, Daejeon, Republic of Korea

  https://orcid.org/0000-0001-8793-2449

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• Jae Kyoung Kim

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hyeseon0128@o.cnu.ac.kr (HSJ); hyyun@cnu.ac.kr (H-yY); jaekkim@kaist.ac.kr (JKK)

  Affiliations Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea, Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea

  https://orcid.org/0000-0001-7842-2172

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