Identifying metabolic adaptations characteristic of cardiotoxicity using paired transcriptomics and metabolomics data integrated with a computational model of heart metabolism

• Bonnie V. Dougherty,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

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• Connor J. Moore,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

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• Kristopher D. Rawls,

  Roles Writing – review & editing

  Affiliation Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0001-5873-0127

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• Matthew L. Jenior,

  Roles Writing – review & editing

  Affiliation Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

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• Bryan Chun,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

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• Sarbajeet Nagdas,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia, United States of America

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• Jeffrey J. Saucerman,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America

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• Glynis L. Kolling,

  Roles Conceptualization, Data curation, Writing – review & editing

  Affiliations Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America, Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, United States of America

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• Anders Wallqvist,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, Maryland, United States of America

  https://orcid.org/0000-0002-9775-7469

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• Jason A. Papin

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: papin@virginia.edu

  Affiliations Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America, Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, United States of America, Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0002-2769-5805

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