It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs

• Yang Jiang,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0003-1100-9177

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• Charlotte M. Deane,

  Roles Writing – review & editing

  Affiliation Oxford Protein Informatics Group, Department of Statistics, University of Oxford, 24-29 St Giles’ Oxford, OX1 3LB United Kingdom

  https://orcid.org/0000-0003-1388-2252

  ⨯
• Garrett M. Morris,

  Roles Resources, Software, Writing – review & editing

  Affiliation Oxford Protein Informatics Group, Department of Statistics, University of Oxford, 24-29 St Giles’ Oxford, OX1 3LB United Kingdom

  https://orcid.org/0000-0003-1731-8405

  ⨯
• Edward P. O’Brien

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: epo2@psu.edu

  Affiliations Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America, Bioinformatics and Genomics Graduate Program, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America, Institute for Computational and Data Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0001-9809-3273

  ⨯