Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data

• Chenyu Wu,

  Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Einar Bjarki Gunnarsson,

  Roles Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations School of Mathematics, University of Minnesota, Minneapolis, Minnesota, United States of America, Applied Mathematics Division, Science Institute, University of Iceland, Reykjavík, Iceland

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• Even Moa Myklebust,

  Roles Methodology, Visualization, Writing – review & editing

  Affiliation Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway

  https://orcid.org/0000-0002-8380-6370

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• Alvaro Köhn-Luque,

  Roles Conceptualization, Methodology, Visualization, Writing – review & editing

  Affiliations Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway, Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway

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• Dagim Shiferaw Tadele,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliations Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Medical Genetics, Oslo University Hospital, Oslo, Norway

  https://orcid.org/0000-0001-8319-678X

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• Jorrit Martijn Enserink,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Section for Biochemistry and Molecular Biology, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway

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• Arnoldo Frigessi,

  Roles Funding acquisition, Methodology, Writing – review & editing

  Affiliation Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway

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• Jasmine Foo,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation School of Mathematics, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Kevin Leder

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lede0024@umn.edu

  Affiliation Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

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