A rule-based multiscale model of hepatic stellate cell plasticity: Critical role of the inactivation loop in fibrosis progression

Matthieu Bouguéon; Vincent Legagneux; Octave Hazard; Jérémy Bomo; Anne Siegel; Jérôme Feret; Nathalie Théret

doi:10.1371/journal.pcbi.1011858

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Peer-reviewed

Research Article

A rule-based multiscale model of hepatic stellate cell plasticity: Critical role of the inactivation loop in fibrosis progression

Matthieu Bouguéon,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Univ Rennes, Inria, CNRS, IRISA, UMR 6074, Rennes, France, Univ Rennes, Inserm, EHESP, Irset, UMR S1085, Rennes, France
⨯
Vincent Legagneux,

Roles Conceptualization, Data curation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Univ Rennes, Inserm, EHESP, Irset, UMR S1085, Rennes, France
⨯
Octave Hazard,

Roles Conceptualization

Affiliations École Polytechnique, Palaiseau, France, DI-ENS (Inria, ÉNS, CNRS, PSL University), École normale supérieure, Paris, France
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Jérémy Bomo,

Roles Investigation

Affiliations Univ Rennes, Inria, CNRS, IRISA, UMR 6074, Rennes, France, Univ Rennes, Inserm, EHESP, Irset, UMR S1085, Rennes, France
⨯
Anne Siegel,

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Univ Rennes, Inria, CNRS, IRISA, UMR 6074, Rennes, France
⨯
Jérôme Feret ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: jerome.feret@ens.fr (JF); nathalie.theret@inserm.fr (NT)

Affiliations DI-ENS (Inria, ÉNS, CNRS, PSL University), École normale supérieure, Paris, France, Team Antique, Inria, Paris, France
⨯
Nathalie Théret

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jerome.feret@ens.fr (JF); nathalie.theret@inserm.fr (NT)

Affiliations Univ Rennes, Inria, CNRS, IRISA, UMR 6074, Rennes, France, Univ Rennes, Inserm, EHESP, Irset, UMR S1085, Rennes, France

https://orcid.org/0000-0002-5857-7828

⨯

A rule-based multiscale model of hepatic stellate cell plasticity: Critical role of the inactivation loop in fibrosis progression

Matthieu Bouguéon,
Vincent Legagneux,
Octave Hazard,
Jérémy Bomo,
Anne Siegel,
Jérôme Feret,
Nathalie Théret

Published: July 29, 2024
https://doi.org/10.1371/journal.pcbi.1011858

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