Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics

• Clare P. McCormack ,

  Roles Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: c.mccormack14@imperial.ac.uk (CPM); oackaert@ITS.JNJ.com (OA)

  Affiliation MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom

  ⨯
• Olivia Goethals,

  Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Janssen Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium

  ⨯
• Nele Goeyvaerts,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium

  ⨯
• Xavier D. Woot de Trixhe,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium

  ⨯
• Peggy Geluykens,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium, Discovery, Charles River Beerse, Beerse, Belgium

  ⨯
• Doortje Borrenberghs,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Janssen Global Public Health, Janssen Pharmaceutica NV, Beerse, Belgium

  ⨯
• Neil M. Ferguson,

  Roles Conceptualization, Methodology, Validation, Writing – review & editing

  Affiliation MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom

  ⨯
• Oliver Ackaert ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – review & editing

  * E-mail: c.mccormack14@imperial.ac.uk (CPM); oackaert@ITS.JNJ.com (OA)

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium

  ⨯
• Ilaria Dorigatti

  Roles Conceptualization, Methodology, Validation, Writing – original draft, Writing – review & editing

  ¶‡ These authors are joint senior authors on this work.

  Affiliation MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom

  https://orcid.org/0000-0001-9959-0706

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