Computational design of novel Cas9 PAM-interacting domains using evolution-based modelling and structural quality assessment

• Cyril Malbranke ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Software, Visualization, Writing – original draft

  * E-mail: cyril.malbranke@phys.ens.fr

  Affiliations Laboratory of Physics of the Ecole Normale Superieure, PSL Research, CNRS UMR 8023, Sorbonne Université, Paris, France, Institut Pasteur, Université Paris Cité, CNRS UMR 6047, Synthetic Biology, Paris, France

  https://orcid.org/0000-0002-4545-0801

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• William Rostain,

  Roles Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR 6047, Synthetic Biology, Paris, France

  https://orcid.org/0000-0002-9960-4669

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• Florence Depardieu,

  Roles Methodology

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR 6047, Synthetic Biology, Paris, France

  https://orcid.org/0000-0002-2680-0589

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• Simona Cocco,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision

  Affiliation Laboratory of Physics of the Ecole Normale Superieure, PSL Research, CNRS UMR 8023, Sorbonne Université, Paris, France

  https://orcid.org/0000-0002-4459-0204

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• Rémi Monasson,

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision

  Affiliation Laboratory of Physics of the Ecole Normale Superieure, PSL Research, CNRS UMR 8023, Sorbonne Université, Paris, France

  https://orcid.org/0000-0002-1852-7789

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• David Bikard

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR 6047, Synthetic Biology, Paris, France

  https://orcid.org/0000-0002-5729-1211

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