Excalibur: A new ensemble method based on an optimal combination of aggregation tests for rare-variant association testing for sequencing data

• Simon Boutry,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft

  Affiliations Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium, Interuniversity Institute of Bioinformatics in Brussels, Université Libre de Bruxelles-Vrije Universiteit Brussels, Brussels, Belgium

  https://orcid.org/0000-0002-3214-2981

  ⨯
• Raphaël Helaers,

  Roles Supervision, Writing – review & editing

  Affiliation Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium

  ⨯
• Tom Lenaerts,

  Roles Project administration, Supervision, Writing – review & editing

  Affiliations Interuniversity Institute of Bioinformatics in Brussels, Université Libre de Bruxelles-Vrije Universiteit Brussels, Brussels, Belgium, Machine Learning Group, Université Libre de Bruxelles, Brussels, Belgium, Artificial Intelligence laboratory, Vrije Universiteit Brussel, Brussels, Belgium

  ⨯
• Miikka Vikkula

  Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: miikka.vikkula@uclouvain.be

  Affiliations Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium, WELBIO department, WEL Research Institute, Wavre, Belgium

  https://orcid.org/0000-0002-6236-338X

  ⨯