Incorporating physics to overcome data scarcity in predictive modeling of protein function: A case study of BK channels

• Erik Nordquist ,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America

  https://orcid.org/0000-0001-9139-0152

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• Guohui Zhang ,

  Roles Data curation, Validation, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Shrishti Barethiya,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America

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• Nathan Ji,

  Roles Data curation, Formal analysis

  Affiliation Department of Biology, Boston College, Chestnut Hill, Massachusetts, United States of America

  https://orcid.org/0000-0001-7246-4814

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• Kelli M. White,

  Roles Data curation

  Affiliation Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Lu Han,

  Roles Data curation

  Affiliation Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Zhiguang Jia,

  Roles Data curation, Methodology

  Affiliation Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America

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• Jingyi Shi,

  Roles Data curation, Supervision

  Affiliation Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Jianmin Cui,

  Roles Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Jianhan Chen

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: jianhanc@umass.edu

  Affiliation Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America

  https://orcid.org/0000-0002-5281-1150

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