Mathematical modeling indicates that regulatory inhibition of CD8⁺ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load

• Jonathan W. Cody,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America

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• Amy L. Ellis-Connell,

  Roles Conceptualization, Data curation, Methodology, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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• Shelby L. O’Connor,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  https://orcid.org/0000-0003-0183-5010

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• Elsje Pienaar

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: epienaar@purdue.edu

  Affiliations Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America, Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, Indiana, United States of America

  https://orcid.org/0000-0002-5408-8795

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