The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia

• Salvador Chulián ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: salvador.chulian@uca.es (SC); helen.byrne@maths.ox.ac.uk (HMB)

  Affiliations Department of Mathematics, Universidad de Cádiz, Puerto Real (Cádiz), Spain, Biomedical Research and Innovation Institute of Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain, Department of Mathematics, Mathematical Oncology Laboratory (MOLAB), Universidad de Castilla-La Mancha, Ciudad Real, Spain

  https://orcid.org/0000-0001-5509-5236

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• Bernadette J. Stolz,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Mathematical Institute, University of Oxford, Oxford, United Kingdom, Laboratory for Topology and Neuroscience, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

  https://orcid.org/0000-0001-8658-8666

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• Álvaro Martínez-Rubio,

  Roles Data curation, Software, Visualization, Writing – review & editing

  Affiliations Department of Mathematics, Universidad de Cádiz, Puerto Real (Cádiz), Spain, Biomedical Research and Innovation Institute of Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain, Department of Mathematics, Mathematical Oncology Laboratory (MOLAB), Universidad de Castilla-La Mancha, Ciudad Real, Spain

  https://orcid.org/0000-0003-1712-2971

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• Cristina Blázquez Goñi,

  Roles Data curation, Project administration, Validation, Writing – review & editing

  Affiliations Biomedical Research and Innovation Institute of Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain, Department of Paediatric Haematology and Oncology, Hospital Universitario de Jerez, Jerez de la Frontera (Cádiz), Spain, Department of Haematology, Hospital Universitario Vírgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain

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• Juan F. Rodríguez Gutiérrez,

  Roles Data curation, Validation, Writing – review & editing

  Affiliations Biomedical Research and Innovation Institute of Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain, Department of Paediatric Haematology and Oncology, Hospital Universitario de Jerez, Jerez de la Frontera (Cádiz), Spain

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• Teresa Caballero Velázquez,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Department of Haematology, Hospital Universitario Vírgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain, CSIC, University of Sevilla, Sevilla, Spain

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• Águeda Molinos Quintana,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Department of Haematology, Hospital Universitario Vírgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain, CSIC, University of Sevilla, Sevilla, Spain

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• Manuel Ramírez Orellana,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Paediatric Haematology and Oncology, Hospital Infantil Universitario Niño Jesús - Instituto Investigación Sanitaria La Princesa, Madrid, Spain

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• Ana Castillo Robleda,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Paediatric Haematology and Oncology, Hospital Infantil Universitario Niño Jesús - Instituto Investigación Sanitaria La Princesa, Madrid, Spain

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• José Luis Fuster Soler,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Paediatric Haematology and Oncology, Hospital Clínico Universitario Virgen de la Arrixaca - Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain

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• Alfredo Minguela Puras,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca - Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain

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• María V. Martínez Sánchez,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca - Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain

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• María Rosa,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Department of Mathematics, Universidad de Cádiz, Puerto Real (Cádiz), Spain, Biomedical Research and Innovation Institute of Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain, Department of Mathematics, Mathematical Oncology Laboratory (MOLAB), Universidad de Castilla-La Mancha, Ciudad Real, Spain

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• Víctor M. Pérez-García,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Department of Mathematics, Mathematical Oncology Laboratory (MOLAB), Universidad de Castilla-La Mancha, Ciudad Real, Spain, Instituto de Matemática Aplicada a la Ciencia y la Ingeniería (IMACI), Universidad de Castilla-La Mancha, Ciudad Real, Spain, ETSI Industriales, Universidad de Castilla-La Mancha, Ciudad Real, Spain

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• Helen M. Byrne

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: salvador.chulian@uca.es (SC); helen.byrne@maths.ox.ac.uk (HMB)

  Affiliation Mathematical Institute, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0003-1771-5910

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