Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers

• Kosaku Kitagawa ,

  Contributed equally to this work with: Kosaku Kitagawa, Kwang Su Kim

  Roles Formal analysis, Methodology, Writing – original draft

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Kwang Su Kim ,

  Contributed equally to this work with: Kosaku Kitagawa, Kwang Su Kim

  Roles Formal analysis, Methodology, Writing – original draft

  Affiliations interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan, Department of Scientific Computing, Pukyong National University, Busan, South Korea

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• Masashi Iwamoto ,

  Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

  ¶‡ MI, SH and HP also contributed equally to this work. KW and SI also contributed equally to this work.

  Affiliations interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan, Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

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• Sanae Hayashi ,

  Roles Data curation, Investigation, Writing – original draft

  ¶‡ MI, SH and HP also contributed equally to this work. KW and SI also contributed equally to this work.

  Affiliation Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

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• Hyeongki Park ,

  Roles Formal analysis, Methodology, Writing – original draft

  ¶‡ MI, SH and HP also contributed equally to this work. KW and SI also contributed equally to this work.

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Takara Nishiyama,

  Roles Formal analysis, Methodology

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Naotoshi Nakamura,

  Roles Formal analysis, Methodology

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

  https://orcid.org/0000-0002-4798-3660

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• Yasuhisa Fujita,

  Roles Formal analysis, Methodology

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Shinji Nakaoka,

  Roles Data curation, Methodology

  Affiliation Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan

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• Kazuyuki Aihara,

  Roles Formal analysis, Methodology

  Affiliation International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan

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• Alan S. Perelson,

  Roles Formal analysis, Methodology

  Affiliation Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, United States of America

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• Lena Allweiss,

  Roles Data curation, Investigation

  Affiliations Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems partner sites, Germany

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• Maura Dandri,

  Roles Data curation, Investigation

  Affiliations Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems partner sites, Germany

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• Koichi Watashi ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: kwatashi@niid.go.jp (KW); iwami.iblab@bio.nagoya-u.ac.jp (SI)

  ¶‡ MI, SH and HP also contributed equally to this work. KW and SI also contributed equally to this work.

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Sciences, Faculty of Science and Technology, Tokyo University of Sciences, Chiba, Japan

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• Yasuhito Tanaka,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

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•  [ ... ],
• Shingo Iwami

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: kwatashi@niid.go.jp (KW); iwami.iblab@bio.nagoya-u.ac.jp (SI)

  ¶‡ MI, SH and HP also contributed equally to this work. KW and SI also contributed equally to this work.

  Affiliations interdisciplinary Biology Laboratory (iBLab), Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya, Japan, Department of Applied Biological Sciences, Faculty of Science and Technology, Tokyo University of Sciences, Chiba, Japan, Institute of Mathematics for Industry, Kyushu University; Fukuoka, Japan, Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University; Kyoto, Japan, NEXT-Ganken Program, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan, Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), RIKEN, Wako, Japan, Science Groove Inc., Fukuoka, Japan

  https://orcid.org/0000-0002-1780-350X

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