High rifampicin peak plasma concentrations accelerate the slow phase of bacterial decline in tuberculosis patients: Evidence for heteroresistance

• Antal Martinecz,

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway, Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America

  https://orcid.org/0000-0001-6539-6358

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• Martin J. Boeree,

  Roles Data curation, Funding acquisition, Writing – review & editing

  Affiliation Department of Lung Diseases, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands

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• Andreas H. Diacon,

  Roles Data curation, Writing – review & editing

  Affiliations Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa, TASK Applied Science, Cape Town, South Africa

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• Rodney Dawson,

  Roles Data curation, Writing – review & editing

  Affiliations Division of Pulmonology and Department of Medicine, University of Cape Town, Cape Town, South Africa, University of Cape Town Lung Institute, Cape Town, South Africa

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• Colin Hemez,

  Roles Writing – review & editing

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Graduate program in Biophysics, Harvard University, Boston, Massachusetts, United States of America

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• Rob E. Aarnoutse,

  Roles Writing – review & editing

  Affiliation Department of Pharmacy, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands

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• Pia Abel zur Wiesch

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: pzw@daad-alumni.de

  Affiliations Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway, Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Department of Biology, Eberly College of Science, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Norwegian Institute of Public Health (Folkehelseinstitutt), Oslo, Norway

  https://orcid.org/0000-0001-9420-9005

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