First passage time analysis of spatial mutation patterns reveals sub-clonal evolutionary dynamics in colorectal cancer

• Magnus J. Haughey ,

  Contributed equally to this work with: Magnus J. Haughey, Aleix Bassolas

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: m.j.haughey@qmul.ac.uk (MJH); v.nicosia@qmul.ac.uk (VN); weini.huang@qmul.ac.uk (WH)

  Affiliation School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom

  https://orcid.org/0000-0003-3329-6648

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• Aleix Bassolas ,

  Contributed equally to this work with: Magnus J. Haughey, Aleix Bassolas

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom

  ⨯
• Sandro Sousa,

  Roles Conceptualization, Formal analysis, Writing – review & editing

  Affiliation School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom

  https://orcid.org/0000-0002-6198-7393

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• Ann-Marie Baker,

  Roles Data curation, Writing – review & editing

  Affiliations Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

  https://orcid.org/0000-0001-8905-9137

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• Trevor A. Graham,

  Roles Supervision, Writing – review & editing

  Affiliations Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom, Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

  https://orcid.org/0000-0001-9582-1597

  ⨯
• Vincenzo Nicosia ,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  * E-mail: m.j.haughey@qmul.ac.uk (MJH); v.nicosia@qmul.ac.uk (VN); weini.huang@qmul.ac.uk (WH)

  Affiliation School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom

  https://orcid.org/0000-0003-0636-3278

  ⨯
• Weini Huang

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  * E-mail: m.j.haughey@qmul.ac.uk (MJH); v.nicosia@qmul.ac.uk (VN); weini.huang@qmul.ac.uk (WH)

  Affiliation School of Mathematical Sciences, Queen Mary University of London, London, United Kingdom

  ⨯