Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction

• Gregory J. Kimmel ,

  Contributed equally to this work with: Gregory J. Kimmel, Richard J. Beck

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation H. Lee Moffitt Cancer Center & Research Institute, Integrated Mathematical Oncology, Tampa, Florida

  https://orcid.org/0000-0001-9766-5399

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• Richard J. Beck ,

  Contributed equally to this work with: Gregory J. Kimmel, Richard J. Beck

  Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation H. Lee Moffitt Cancer Center & Research Institute, Integrated Mathematical Oncology, Tampa, Florida

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• Xiaoqing Yu,

  Roles Data curation, Resources, Visualization, Writing – review & editing

  Affiliation H. Lee Moffitt Cancer Center & Research Institute, Biostatistics & Bioinformatics, Tampa, Florida

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• Thomas Veith,

  Roles Data curation, Resources, Visualization

  Affiliation H. Lee Moffitt Cancer Center & Research Institute, Integrated Mathematical Oncology, Tampa, Florida

  https://orcid.org/0000-0001-8411-9911

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• Samuel Bakhoum,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program, New York City, New York

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• Philipp M. Altrock,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  Affiliation Max Planck Institute for Evolutionary Biology, Department for Evolutionary Theory, Plön, Germany

  https://orcid.org/0000-0001-7731-3345

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• Noemi Andor

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: noemi.andor@gmail.com

  Affiliation H. Lee Moffitt Cancer Center & Research Institute, Integrated Mathematical Oncology, Tampa, Florida

  https://orcid.org/0000-0002-2469-5180

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