Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites

Rong Gao; Samantha E. Brokaw; Zeyue Li; Libby J. Helfant; Ti Wu; Muhammad Malik; Ann M. Stock

doi:10.1371/journal.pcbi.1010738

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Peer-reviewed

Research Article

Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites

Rong Gao,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Samantha E. Brokaw,

Roles Data curation, Investigation

Affiliation Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Zeyue Li,

Roles Data curation, Investigation

Affiliation Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Libby J. Helfant,

Roles Investigation

Affiliation Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Ti Wu,

Roles Investigation

Affiliation Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Muhammad Malik,

Roles Investigation

Affiliation Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
⨯
Ann M. Stock

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: stock@cabm.rutgers.edu

Affiliation Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Molecular Biology, Rutgers University - Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America

https://orcid.org/0000-0002-0446-8079

⨯

Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites

Rong Gao,
Samantha E. Brokaw,
Zeyue Li,
Libby J. Helfant,
Ti Wu,
Muhammad Malik,
Ann M. Stock

Published: November 22, 2022
https://doi.org/10.1371/journal.pcbi.1010738

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Escherichia coli
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DNA-binding proteins
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