Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models

• Javiera Cortés-Ríos,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Chile

  https://orcid.org/0000-0002-1501-8081

  ⨯
• Ramón C. Hermida,

  Roles Writing – review & editing

  Affiliations Bioengineering & Chronobiology Laboratories, Atlantic Research Center for Telecommunication Technologies (atlanTTic), Universidade de Vigo, Vigo, Spain, Bioengineering & Chronobiology Research Group. Galicia Sur Health Research Institute (IIS Galicia Sur). SERGAS-UVIGO, Vigo, Spain

  https://orcid.org/0000-0002-8853-5901

  ⨯
• Maria Rodriguez-Fernandez

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: marodriguezf@uc.cl

  Affiliation Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Chile

  https://orcid.org/0000-0003-1966-2920

  ⨯