Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins

Zahra Maqsood; Joanne C. Clark; Eleyna M. Martin; Yam Fung Hilaire Cheung; Luis A. Morán; Sean E. T. Watson; Jeremy A. Pike; Ying Di; Natalie S. Poulter; Alexandre Slater; Bodo M. H. Lange; Bernhard Nieswandt; Johannes A. Eble; Mike G. Tomlinson; Dylan M. Owen; David Stegner; Lloyd J. Bridge; Christoph Wierling; Steve P. Watson

doi:10.1371/journal.pcbi.1010708

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Peer-reviewed

Research Article

Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins

Zahra Maqsood ,

Contributed equally to this work with: Zahra Maqsood, Joanne C. Clark, Eleyna M. Martin

Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Writing – original draft, Writing – review & editing

Affiliations Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Alacris Theranostics, GmbH, Berlin, Germany, Rudolf Virchow Center for Integrative and Translation Bioimaging, University of Würzburg and Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany
⨯
Joanne C. Clark ,

Contributed equally to this work with: Zahra Maqsood, Joanne C. Clark, Eleyna M. Martin

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, United Kingdom
⨯
Eleyna M. Martin ,

Contributed equally to this work with: Zahra Maqsood, Joanne C. Clark, Eleyna M. Martin

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
⨯
Yam Fung Hilaire Cheung,

Roles Data curation, Investigation, Software, Writing – review & editing

Affiliations Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Leibniz-Institut für Analytische Wissenschaften–ISAS—e. V., Dortmund, Germany, School of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands

https://orcid.org/0000-0003-0917-5918

⨯
Luis A. Morán,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
⨯
Sean E. T. Watson,

Roles Conceptualization, Software, Writing – review & editing

Affiliation Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
⨯
Jeremy A. Pike,

Roles Software, Supervision, Writing – review & editing

Affiliations Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, United Kingdom
⨯
Ying Di,

Roles Investigation, Writing – review & editing

Affiliation Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
⨯
Natalie S. Poulter,

Roles Funding acquisition, Writing – review & editing

Affiliations Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, United Kingdom
⨯
Alexandre Slater,

Roles Methodology, Writing – review & editing

Affiliation Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

https://orcid.org/0000-0001-7166-438X

⨯
Bodo M. H. Lange,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Alacris Theranostics, GmbH, Berlin, Germany
⨯
Bernhard Nieswandt,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Rudolf Virchow Center for Integrative and Translation Bioimaging, University of Würzburg and Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany
⨯
Johannes A. Eble,

Roles Resources, Writing – review & editing

Affiliation Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany

https://orcid.org/0000-0001-9156-2137

⨯
Mike G. Tomlinson,

Roles Funding acquisition, Writing – review & editing

Affiliations Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, United Kingdom, Department of Biosciences, University of Birmingham, Birmingham, United Kingdom
⨯
Dylan M. Owen,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, United Kingdom, Institute of Immunology and Immunotherapy, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
⨯
David Stegner,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Rudolf Virchow Center for Integrative and Translation Bioimaging, University of Würzburg and Institute of Experimental Biomedicine I, University Hospital of Würzburg, Würzburg, Germany

https://orcid.org/0000-0003-1059-9865

⨯
Lloyd J. Bridge,

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Faculty of Environment & Technology, Department of Computer Science and Creative Technologies, University of the West England, Bristol, United Kingdom
⨯
Christoph Wierling ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: c.wierling@alacris.de (CW); s.p.watson@bham.ac.uk (SPW)

Affiliation Alacris Theranostics, GmbH, Berlin, Germany
⨯
[ ... ],
Steve P. Watson

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: c.wierling@alacris.de (CW); s.p.watson@bham.ac.uk (SPW)

Affiliations Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, United Kingdom, School of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands
⨯
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Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins

Zahra Maqsood,
Joanne C. Clark,
Eleyna M. Martin,
Yam Fung Hilaire Cheung,
Luis A. Morán,
Sean E. T. Watson,
Jeremy A. Pike,
Ying Di,
Natalie S. Poulter,
Alexandre Slater

Published: November 28, 2022
https://doi.org/10.1371/journal.pcbi.1010708

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Dimerization
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Platelet aggregation
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SH2 domains
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