Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research

• Belén Casas,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, Department of Biomedical Engineering, Linköping University, Linköping, Sweden

  https://orcid.org/0000-0003-2479-1751

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• Liisa Vilén,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Writing – review & editing

  Affiliation Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Sophie Bauer,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation TissUse GmbH, Berlin, Germany

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• Kajsa P. Kanebratt,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Charlotte Wennberg Huldt,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Lisa Magnusson,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Uwe Marx,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation TissUse GmbH, Berlin, Germany

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• Tommy B. Andersson,

  Roles Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Peter Gennemark ,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – review & editing

  ¶‡ These authors are shared senior authors on this work.

  Affiliations Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, Department of Biomedical Engineering, Linköping University, Linköping, Sweden

  https://orcid.org/0000-0002-7865-7454

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• Gunnar Cedersund

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: gunnar.cedersund@liu.se

  ¶‡ These authors are shared senior authors on this work.

  Affiliations Department of Biomedical Engineering, Linköping University, Linköping, Sweden, Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden

  https://orcid.org/0000-0001-9386-0568

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