Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies

• Carolin Zitzmann ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  * E-mail: czitzmann@lanl.gov (CZ); lars.kaderali@uni-greifswald.de (LK)

  Affiliations Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany, Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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• Christopher Dächert,

  Roles Data curation, Investigation, Writing – review & editing

  Current address: Max von Pettenkofer Institute, Ludwig-Maximilians-University München, Germany

  Affiliation Research Group "Dynamics of Early Viral Infection and the Innate Antiviral Response", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany

  https://orcid.org/0000-0001-6441-3099

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• Bianca Schmid,

  Roles Data curation, Investigation

  Affiliation Dept of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany

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• Hilde van der Schaar,

  Roles Data curation, Investigation

  Current address: VectorY Therapeutics, Amsterdam, The Netherlands

  Affiliation Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands

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• Martijn van Hemert,

  Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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• Alan S. Perelson,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  https://orcid.org/0000-0002-2455-0002

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• Frank J. M. van Kuppeveld,

  Roles Funding acquisition, Resources, Supervision, Writing – original draft

  Affiliation Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands

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• Ralf Bartenschlager,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Division of infectious Diseases and Immunology, Virology Section, Dept of Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands, Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany, German Center for Infection Research (DZIF), Heidelberg partner site, Heidelberg, Germany

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• Marco Binder,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Research Group "Dynamics of Early Viral Infection and the Innate Antiviral Response", Division Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Lars Kaderali

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: czitzmann@lanl.gov (CZ); lars.kaderali@uni-greifswald.de (LK)

  Affiliation Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany

  https://orcid.org/0000-0002-2359-2294

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