Deep learning prediction of chemical-induced dose-dependent and context-specific multiplex phenotype responses and its application to personalized alzheimer’s disease drug repurposing

• You Wu ,

  Contributed equally to this work with: You Wu, Qiao Liu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Ph.D. Program in Computer Science, The Graduate Center, The City University of New York, New York city, New York, United States of America

  https://orcid.org/0000-0003-4807-8504

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• Qiao Liu ,

  Contributed equally to this work with: You Wu, Qiao Liu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Meta Inc., Menlo Park, California, United States of America

  Affiliation Department of Computer Science, Hunter College, The City University of New York, New York city, New York, United States of America

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• Yue Qiu,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Writing – review & editing

  Affiliation Ph.D. Program in Biology, The Graduate Center, The City University of New York, New York city, New York, United States of America

  https://orcid.org/0000-0001-9692-1290

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• Lei Xie

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: lei.xie@hunter.cuny.edu

  Affiliations Ph.D. Program in Computer Science, The Graduate Center, The City University of New York, New York city, New York, United States of America, Department of Computer Science, Hunter College, The City University of New York, New York city, New York, United States of America, Ph.D. Program in Biology, The Graduate Center, The City University of New York, New York city, New York, United States of America, Helen and Robert Appel Alzheimer’s Disease Research Institute, Feil Family Brain & Mind Research Institute, Weill Cornell Medicine, Cornell University, New York city, New York, United States of America

  https://orcid.org/0000-0001-9051-2111

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