De novo spatiotemporal modelling of cell-type signatures in the developmental human heart using graph convolutional neural networks

Sergio Marco Salas; Xiao Yuan; Christer Sylven; Mats Nilsson; Carolina Wählby; Gabriele Partel

doi:10.1371/journal.pcbi.1010366

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Open Access

Peer-reviewed

Research Article

De novo spatiotemporal modelling of cell-type signatures in the developmental human heart using graph convolutional neural networks

Sergio Marco Salas,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Software, Visualization, Writing – original draft

Affiliation Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden
⨯
Xiao Yuan,

Roles Data curation, Formal analysis, Investigation, Resources, Software, Writing – review & editing

Affiliation Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden

https://orcid.org/0000-0001-9788-7717

⨯
Christer Sylven,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Department of Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden
⨯
Mats Nilsson ,

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: mats.nilsson@scilifelab.se (MN); carolina.wahlby@it.uu.se (CW); gabriele.partel@kuleuven.be (GP)

Affiliation Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden

https://orcid.org/0000-0001-9985-0387

⨯
Carolina Wählby ,

Roles Conceptualization, Software, Supervision, Writing – review & editing

* E-mail: mats.nilsson@scilifelab.se (MN); carolina.wahlby@it.uu.se (CW); gabriele.partel@kuleuven.be (GP)

Affiliation Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden

https://orcid.org/0000-0002-4139-7003

⨯
Gabriele Partel

Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mats.nilsson@scilifelab.se (MN); carolina.wahlby@it.uu.se (CW); gabriele.partel@kuleuven.be (GP)

Affiliations Department of Information Technology and Science for Life Laboratory Uppsala University, Uppsala, Sweden, Laboratory of Multi-omic Integrative Bioinformatics, Department of Human Genetics, KU Leuven, Leuven, Belgium, VIB-KU Leuven Center for Brain & Disease Research, Laboratory of Computational Biology, Department of Human Genetics, Leuven, Belgium

https://orcid.org/0000-0002-4482-3119

⨯

De novo spatiotemporal modelling of cell-type signatures in the developmental human heart using graph convolutional neural networks

Sergio Marco Salas,
Xiao Yuan,
Christer Sylven,
Mats Nilsson,
Carolina Wählby,
Gabriele Partel

Published: August 12, 2022
https://doi.org/10.1371/journal.pcbi.1010366

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Gene expression
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Cardiomyocytes
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Gene ontologies
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Heart development
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Cell differentiation
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Cardiac atria
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Myocardium
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Transcriptome analysis
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