Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines

• Joonas P. Kosonen ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  * E-mail: joonas.kosonen@uef.fi

  Affiliation Department of Technical Physics, University of Eastern Finland, Kuopio, Finland

  https://orcid.org/0000-0001-6063-6914

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• Atte S. A. Eskelinen,

  Roles Conceptualization, Data curation, Investigation, Methodology, Software, Validation, Writing – review & editing

  Affiliation Department of Technical Physics, University of Eastern Finland, Kuopio, Finland

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• Gustavo A. Orozco,

  Roles Conceptualization, Data curation, Investigation, Methodology, Software, Writing – review & editing

  Affiliations Department of Technical Physics, University of Eastern Finland, Kuopio, Finland, Department of Biomedical Engineering, Lund University, Lund, Sweden

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• Petteri Nieminen,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland

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• Donald D. Anderson,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Departments of Orthopedics & Rehabilitation and Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States of America

  https://orcid.org/0000-0002-1640-6107

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• Alan J. Grodzinsky,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Departments of Biological Engineering, Electrical Engineering and Computer Science, and Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Rami K. Korhonen,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Technical Physics, University of Eastern Finland, Kuopio, Finland

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• Petri Tanska

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Technical Physics, University of Eastern Finland, Kuopio, Finland

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