Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling

• Niklas Kolbe ,

  Contributed equally to this work with: Niklas Kolbe, Lorenz Hexemer

  Roles Conceptualization, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: kolbe@igpm.rwth-aachen.de (NK); legewie@ibmg.uni-stuttgart.de (SL)

  Affiliation Institute of Geometry and Practical Mathematics, RWTH Aachen University, Aachen, Germany

  https://orcid.org/0000-0003-0319-8748

  ⨯
• Lorenz Hexemer ,

  Contributed equally to this work with: Niklas Kolbe, Lorenz Hexemer

  Roles Conceptualization, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Molecular Biology (IMB), Mainz, Germany, Department of Systems Biology, Institute for Biomedical Genetics (IBMG), University of Stuttgart, Stuttgart, Germany

  https://orcid.org/0000-0001-6512-7190

  ⨯
• Lukas-Malte Bammert,

  Roles Investigation, Software, Writing – review & editing

  Affiliation Institute of Mathematics, Johannes Gutenberg-University, Mainz, Germany

  https://orcid.org/0000-0002-0274-5343

  ⨯
• Alexander Loewer,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Systems Biology of the Stress Response, Department of Biology, Technical University of Darmstadt, Darmstadt, Germany

  https://orcid.org/0000-0002-8819-3040

  ⨯
• Mária Lukáčová-Medvid’ová ,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  ¶‡ MLM and SL also contributed equally to this work.

  Affiliation Institute of Mathematics, Johannes Gutenberg-University, Mainz, Germany

  ⨯
• Stefan Legewie

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: kolbe@igpm.rwth-aachen.de (NK); legewie@ibmg.uni-stuttgart.de (SL)

  ¶‡ MLM and SL also contributed equally to this work.

  Affiliations Department of Systems Biology, Institute for Biomedical Genetics (IBMG), University of Stuttgart, Stuttgart, Germany, Stuttgart Research Center for Systems Biology (SRCSB), University of Stuttgart, Stuttgart, Germany

  ⨯