Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model

• Alvaro Ruiz-Martinez ,

  Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: alvrm86@gmail.com

  Affiliation Department of Biomedical Engineering, Johns Hopkins, University School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0001-9899-8558

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• Chang Gong,

  Roles Conceptualization, Methodology, Software, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Johns Hopkins, University School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-1315-8638

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• Hanwen Wang,

  Roles Resources, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Johns Hopkins, University School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0001-5480-431X

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• Richard J. Sové,

  Roles Resources, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Johns Hopkins, University School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0003-1491-616X

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• Haoyang Mi,

  Roles Resources, Writing – review & editing

  Affiliation Department of Biomedical Engineering, Johns Hopkins, University School of Medicine, Baltimore, Maryland, United States of America

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• Holly Kimko,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Clinical Pharmacology & Quantitative Pharmacology, AstraZeneca, Gaithersburg, Maryland, United States of America

  https://orcid.org/0000-0003-1456-4862

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• Aleksander S. Popel

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliations Department of Biomedical Engineering, Johns Hopkins, University School of Medicine, Baltimore, Maryland, United States of America, Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

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