A topological data analytic approach for discovering biophysical signatures in protein dynamics

• Wai Shing Tang ,

  Contributed equally to this work with: Wai Shing Tang, Gabriel Monteiro da Silva

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics, Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0001-7759-7771

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• Gabriel Monteiro da Silva ,

  Contributed equally to this work with: Wai Shing Tang, Gabriel Monteiro da Silva

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular and Cell Biology, Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0002-9665-7597

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• Henry Kirveslahti,

  Roles Methodology, Software, Writing – review & editing

  Affiliation Department of Statistical Science, Duke University, Durham, North Carolina, United States of America

  https://orcid.org/0000-0002-2484-4481

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• Erin Skeens,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Molecular and Cell Biology, Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0002-0580-1291

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• Bibo Feng,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Chemistry, Brown University, Providence, Rhode Island, United States of America

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• Timothy Sudijono,

  Roles Investigation, Methodology, Software, Writing – review & editing

  Affiliation Department of Statistics, Stanford University, Palo Alto, California, United States of America

  https://orcid.org/0000-0002-6075-0378

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• Kevin K. Yang,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Microsoft Research New England, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0001-9045-6826

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• Sayan Mukherjee,

  Roles Investigation, Methodology, Software, Supervision, Writing – review & editing

  Affiliations Department of Statistical Science, Duke University, Durham, North Carolina, United States of America, Department of Computer Science, Duke University, Durham, North Carolina, United States of America, Department of Mathematics, Duke University, Durham, North Carolina, United States of America, Department of Bioinformatics & Biostatistics, Duke University, Durham, North Carolina, United States of America

  https://orcid.org/0000-0002-6715-3920

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• Brenda Rubenstein ,

  Roles Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶BR and LC also contributed equally to this work.

  Affiliation Department of Chemistry, Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0003-1643-0358

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• Lorin Crawford

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lcrawford@microsoft.com

  ¶BR and LC also contributed equally to this work.

  Affiliations Microsoft Research New England, Cambridge, Massachusetts, United States of America, Department of Biostatistics, Brown University, Providence, Rhode Island, United States of America, Center for Computational Molecular Biology, Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0003-0178-8242

  ⨯