Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation

• Fei Xiao ,

  Contributed equally to this work with: Fei Xiao, Ziyun Zhou

  Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – original draft

  Affiliation Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China

  https://orcid.org/0000-0001-5262-2475

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• Ziyun Zhou ,

  Contributed equally to this work with: Fei Xiao, Ziyun Zhou

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China

  https://orcid.org/0000-0002-2668-6907

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• Xingyu Song,

  Roles Data curation, Methodology

  Affiliation Department of Chemistry, Multiscale Research Institute of Complex Systems and Institute of Biomedical Sciences, Fudan University, Shanghai, China

  https://orcid.org/0000-0003-1154-7864

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• Mi Gan,

  Roles Formal analysis

  Affiliation Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China

  https://orcid.org/0000-0002-3292-3921

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• Jie Long,

  Roles Data curation, Methodology

  Affiliation Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China

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• Gennady Verkhivker,

  Roles Project administration, Supervision, Writing – review & editing

  Affiliations Department of Computational and Data Sciences, Chapman University, One University Drive, Orange, California, United States of America, Department of Biomedical and Pharmaceutical Sciences, Chapman University Pharmacy School 9401 Jeronimo Rd, Irvine, California, United States of America

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• Guang Hu

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: huguang@suda.edu.cn

  Affiliation Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China

  https://orcid.org/0000-0002-8754-1541

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