Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants

• Nicholas J. Ose,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics and Center for Biological Physics, Arizona State University, Tempe, Arizona, United States of America

  https://orcid.org/0000-0002-2194-5199

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• Brandon M. Butler ,

  Contributed equally to this work with: Brandon M. Butler, Avishek Kumar

  Roles Conceptualization, Data curation, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics and Center for Biological Physics, Arizona State University, Tempe, Arizona, United States of America

  ⨯
• Avishek Kumar ,

  Contributed equally to this work with: Brandon M. Butler, Avishek Kumar

  Roles Conceptualization, Data curation, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Physics and Center for Biological Physics, Arizona State University, Tempe, Arizona, United States of America

  https://orcid.org/0000-0002-9911-3640

  ⨯
• I. Can Kazan,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Department of Physics and Center for Biological Physics, Arizona State University, Tempe, Arizona, United States of America

  https://orcid.org/0000-0003-2593-4179

  ⨯
• Maxwell Sanderford,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, Pennsylvania, United States of America, Department of Biology, Temple University, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-8173-9952

  ⨯
• Sudhir Kumar ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: s.kumar@temple.edu (SK); Banu.Ozkan@asu.edu (SBO)

  Affiliations Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, Pennsylvania, United States of America, Department of Biology, Temple University, Philadelphia, Pennsylvania, United States of America, Center for Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia

  https://orcid.org/0000-0002-9918-8212

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• S. Banu Ozkan

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: s.kumar@temple.edu (SK); Banu.Ozkan@asu.edu (SBO)

  Affiliation Department of Physics and Center for Biological Physics, Arizona State University, Tempe, Arizona, United States of America

  https://orcid.org/0000-0002-9351-3758

  ⨯