Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics

• Erich Hellemann ,

  Contributed equally to this work with: Erich Hellemann, Jennifer L. Walker, Mitchell A. Lesko

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-5565-8614

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• Jennifer L. Walker ,

  Contributed equally to this work with: Erich Hellemann, Jennifer L. Walker, Mitchell A. Lesko

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-1220-1574

  ⨯
• Mitchell A. Lesko ,

  Contributed equally to this work with: Erich Hellemann, Jennifer L. Walker, Mitchell A. Lesko

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-7788-0005

  ⨯
• Dakshayini G. Chandrashekarappa,

  Roles Formal analysis, Investigation, Methodology

  Affiliation University of Pittsburgh School of Medicine, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Martin C. Schmidt,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation University of Pittsburgh School of Medicine, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Allyson F. O’Donnell ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: allyod@pitt.edu (AFO); durrantj@pitt.edu (JDD)

  Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-0966-288X

  ⨯
• Jacob D. Durrant

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: allyod@pitt.edu (AFO); durrantj@pitt.edu (JDD)

  Affiliation Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-5808-4097

  ⨯