Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants

• Stuart A. MacGowan ,

  Contributed equally to this work with: Stuart A. MacGowan, Michael I. Barton

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Computational Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, United Kingdom

  https://orcid.org/0000-0003-4233-5071

  ⨯
• Michael I. Barton ,

  Contributed equally to this work with: Stuart A. MacGowan, Michael I. Barton

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford, Oxfordshire, United Kingdom

  https://orcid.org/0000-0002-9263-6481

  ⨯
• Mikhail Kutuzov,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford, Oxfordshire, United Kingdom

  https://orcid.org/0000-0003-3386-4350

  ⨯
• Omer Dushek,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford, Oxfordshire, United Kingdom

  https://orcid.org/0000-0001-5847-5226

  ⨯
• P. Anton van der Merwe ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: anton.vandermerwe@path.ox.ac.uk (PAvdM); g.j.barton@dundee.ac.uk (GJB)

  Affiliation Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford, Oxfordshire, United Kingdom

  ⨯
• Geoffrey J. Barton

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: anton.vandermerwe@path.ox.ac.uk (PAvdM); g.j.barton@dundee.ac.uk (GJB)

  Affiliation Division of Computational Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, United Kingdom

  https://orcid.org/0000-0002-9014-5355

  ⨯