Predicting drug polypharmacology from cell morphology readouts using variational autoencoder latent space arithmetic

• Yuen Ler Chow,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Current address: Harvard College, Cambridge, Massachusetts, United States of America

  Affiliations Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Brookline High School, Brookline, Massachusetts, United States of America

  https://orcid.org/0000-0003-4239-9518

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• Shantanu Singh,

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0003-3150-3025

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• Anne E. Carpenter,

  Roles Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0003-1555-8261

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• Gregory P. Way

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: gregory.way@cuanschutz.edu

  Affiliations Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Health AI and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America

  https://orcid.org/0000-0002-0503-9348

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