Deep mendelian randomization: Investigating the causal knowledge of genomic deep learning models

Stephen Malina; Daniel Cizin; David A. Knowles

doi:10.1371/journal.pcbi.1009880

Loading metrics

Open Access

Peer-reviewed

Research Article

Deep mendelian randomization: Investigating the causal knowledge of genomic deep learning models

Stephen Malina ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: stephenmalina@gmail.com, stephen.malina@dynotx.com

¤ Current address: Dyno Therapeutics, Watertown, MA, United States of America

Affiliations Department of Computer Science, Columbia University, New York, New York, United States of America, Dyno Therapeutics, Watertown, Massachusetts, United States of America

https://orcid.org/0000-0002-7383-0094

⨯
Daniel Cizin,

Roles Conceptualization, Methodology, Software, Visualization, Writing – review & editing

Affiliations Department of Computer Science, Columbia University, New York, New York, United States of America, Tri-Institutional Ph.D. Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, New York, United States of America

https://orcid.org/0000-0002-6908-6792

⨯
David A. Knowles

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliations Department of Computer Science, Columbia University, New York, New York, United States of America, New York Genome Center, New York, New York, United States of America, Department of Systems Biology, Columbia University, New York, New York, United States of America, Data Science Institute, Columbia University, New York, New York, United States of America

https://orcid.org/0000-0002-7408-146X

⨯

Deep mendelian randomization: Investigating the causal knowledge of genomic deep learning models

Stephen Malina,
Daniel Cizin,
David A. Knowles

Published: October 20, 2022
https://doi.org/10.1371/journal.pcbi.1009880

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Sequence motif analysis
Is the Subject Area "Sequence motif analysis" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
Mutagenesis
Is the Subject Area "Mutagenesis" applicable to this article?

Thanks for your feedback.
Metaanalysis
Is the Subject Area "Metaanalysis" applicable to this article?

Thanks for your feedback.
Simulation and modeling
Is the Subject Area "Simulation and modeling" applicable to this article?

Thanks for your feedback.
Machine learning
Is the Subject Area "Machine learning" applicable to this article?

Thanks for your feedback.
Deep learning
Is the Subject Area "Deep learning" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.