Time to revisit the endpoint dilution assay and to replace the TCID₅₀ as a measure of a virus sample’s infection concentration

• Daniel Cresta ,

  Contributed equally to this work with: Daniel Cresta, Donald C. Warren

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Physics and Astronomy, Western University, London, Ontario, Canada

  Affiliation Department of Physics, Ryerson University, Toronto, Ontario, Canada

  https://orcid.org/0000-0001-7524-9001

  ⨯
• Donald C. Warren ,

  Contributed equally to this work with: Daniel Cresta, Donald C. Warren

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS) program, RIKEN, Wako-shi, Saitama, Japan

  https://orcid.org/0000-0002-3222-9059

  ⨯
• Christian Quirouette,

  Roles Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

  Affiliation Department of Physics, Ryerson University, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-9461-6660

  ⨯
• Amanda P. Smith,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0003-2428-1620

  ⨯
• Lindey C. Lane,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-9600-0472

  ⨯
• Amber M. Smith,

  Roles Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-7092-6904

  ⨯
• Catherine A. A. Beauchemin

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cbeau@ryerson.ca

  Affiliations Department of Physics, Ryerson University, Toronto, Ontario, Canada, Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS) program, RIKEN, Wako-shi, Saitama, Japan

  https://orcid.org/0000-0003-0599-0069

  ⨯