Drug-induced resistance evolution necessitates less aggressive treatment

Teemu Kuosmanen; Johannes Cairns; Robert Noble; Niko Beerenwinkel; Tommi Mononen; Ville Mustonen

doi:10.1371/journal.pcbi.1009418

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Open Access

Peer-reviewed

Research Article

Drug-induced resistance evolution necessitates less aggressive treatment

Teemu Kuosmanen ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

* E-mail: teemu.kuosmanen@helsinki.fi (TK); v.mustonen@helsinki.fi (VM)

Affiliation Organismal and Evolutionary Biology Research Programme, Department of Computer Science, University of Helsinki, Helsinki, Finland

https://orcid.org/0000-0002-8724-5048

⨯
Johannes Cairns,

Roles Investigation, Writing – review & editing

Affiliation Organismal and Evolutionary Biology Research Programme, Department of Computer Science, University of Helsinki, Helsinki, Finland

https://orcid.org/0000-0003-1329-2025

⨯
Robert Noble,

Roles Investigation, Writing – review & editing

Affiliations Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland, Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland, Present address: Department of Mathematics, City, University of London, London, United Kingdom

https://orcid.org/0000-0002-8057-4252

⨯
Niko Beerenwinkel,

Roles Investigation, Writing – review & editing

Affiliation Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

https://orcid.org/0000-0002-0573-6119

⨯
Tommi Mononen,

Roles Investigation, Software, Writing – review & editing

Affiliation Organismal and Evolutionary Biology Research Programme, Department of Computer Science, University of Helsinki, Helsinki, Finland

https://orcid.org/0000-0002-3603-0813

⨯
Ville Mustonen

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: teemu.kuosmanen@helsinki.fi (TK); v.mustonen@helsinki.fi (VM)

Affiliations Organismal and Evolutionary Biology Research Programme, Department of Computer Science, University of Helsinki, Helsinki, Finland, Institute of Biotechnology, Helsinki Institute for Information Technology, University of Helsinki, Helsinki, Finland

https://orcid.org/0000-0002-7270-1792

⨯

Drug-induced resistance evolution necessitates less aggressive treatment

Teemu Kuosmanen,
Johannes Cairns,
Robert Noble,
Niko Beerenwinkel,
Tommi Mononen,
Ville Mustonen

Published: September 23, 2021
https://doi.org/10.1371/journal.pcbi.1009418

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