Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

Rui Yin; Johnathan D. Guest; Ghazaleh Taherzadeh; Ragul Gowthaman; Ipsa Mittra; Jane Quackenbush; Brian G. Pierce

doi:10.1371/journal.pcbi.1009380

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Open Access

Peer-reviewed

Research Article

Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

Rui Yin,

Roles Conceptualization, Data curation, Investigation, Writing – original draft, Writing – review & editing

Affiliations University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland, United States of America, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

https://orcid.org/0000-0001-5330-8306

⨯
Johnathan D. Guest,

Roles Data curation, Investigation, Writing – review & editing

Affiliations University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland, United States of America, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

https://orcid.org/0000-0003-1521-5242

⨯
Ghazaleh Taherzadeh,

Roles Data curation, Investigation, Writing – review & editing

Current address: Department of Mathematics and Computer Science, Wilkes University, Wilkes-Barre, Pennsylvania, United States of America

Affiliations University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland, United States of America, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
⨯
Ragul Gowthaman,

Roles Data curation, Investigation, Writing – review & editing

Affiliations University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland, United States of America, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
⨯
Ipsa Mittra,

Roles Data curation

Affiliations University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland, United States of America, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

https://orcid.org/0000-0002-0482-4037

⨯
Jane Quackenbush,

Roles Data curation

Affiliations University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland, United States of America, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
⨯
Brian G. Pierce

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: pierce@umd.edu

Affiliations University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland, United States of America, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America

https://orcid.org/0000-0003-4821-0368

⨯

Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

Rui Yin,
Johnathan D. Guest,
Ghazaleh Taherzadeh,
Ragul Gowthaman,
Ipsa Mittra,
Jane Quackenbush,
Brian G. Pierce

Published: September 7, 2021
https://doi.org/10.1371/journal.pcbi.1009380

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Hierarchical clustering
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Binding analysis
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