Modeling Na_V1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine

• Louisiane Lemaire ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: louisiane.lemaire@inria.fr (LL); mantegazza@ipmc.cnrs.fr (MM)

  Affiliations Inria Sophia Antipolis Méditerranée Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France, Université Côte d’Azur, Nice, France

  https://orcid.org/0000-0002-9260-2521

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• Mathieu Desroches,

  Roles Conceptualization, Formal analysis, Funding acquisition, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Inria Sophia Antipolis Méditerranée Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France, Université Côte d’Azur, Nice, France

  https://orcid.org/0000-0002-9325-4207

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• Martin Krupa,

  Roles Conceptualization, Data curation, Supervision

  Affiliations Inria Sophia Antipolis Méditerranée Research Centre, MathNeuro Team, Valbonne-Sophia Antipolis, France, Université Côte d’Azur, Laboratoire Jean-Alexandre Dieudonné, Nice, France

  https://orcid.org/0000-0001-9330-4705

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• Lara Pizzamiglio,

  Roles Formal analysis, Investigation

  Affiliations Université Côte d’Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France, CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France

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• Paolo Scalmani,

  Roles Formal analysis, Investigation

  Affiliation U.O. VII Clinical and Experimental Epileptology, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy

  https://orcid.org/0000-0002-3992-0926

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• Massimo Mantegazza

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: louisiane.lemaire@inria.fr (LL); mantegazza@ipmc.cnrs.fr (MM)

  Affiliations Université Côte d’Azur, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France, CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France, Inserm, Valbonne-Sophia Antipolis, France

  https://orcid.org/0000-0002-1070-7929

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