Integration of a physiologically-based pharmacokinetic model with a whole-body, organ-resolved genome-scale model for characterization of ethanol and acetaldehyde metabolism

• Leo Zhu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0003-3492-3981

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• William Pei,

  Roles Investigation, Methodology, Software, Writing – original draft

  Affiliations Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada, Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0001-5401-1440

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• Ines Thiele ,

  Roles Conceptualization, Funding acquisition, Methodology, Software, Writing – review & editing

  * E-mail: ines.thiele@nuigalway.ie (IT); krishna.mahadevan@utoronto.ca (RM)

  Affiliations School of Medicine, National University of Ireland at Galway, Galway, Ireland, Discipline of Microbiology, National University of Ireland at Galway, Galway, Ireland, APC Microbiome Ireland, Cork, Ireland

  https://orcid.org/0000-0002-8071-7110

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• Radhakrishnan Mahadevan

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Software, Supervision, Visualization, Writing – review & editing

  * E-mail: ines.thiele@nuigalway.ie (IT); krishna.mahadevan@utoronto.ca (RM)

  Affiliations Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada, Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-1270-9063

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