A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism

• Linnea Österberg,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft

  Affiliations Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden, Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

  https://orcid.org/0000-0002-9816-6476

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• Iván Domenzain,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliations Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden, Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden

  https://orcid.org/0000-0002-5322-2040

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• Julia Münch,

  Roles Data curation, Investigation, Methodology, Visualization

  Affiliations Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden, Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden

  https://orcid.org/0000-0002-9588-2274

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• Jens Nielsen,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden, Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden, BioInnovation Institute, Copenhagen, Denmark

  https://orcid.org/0000-0002-9955-6003

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• Stefan Hohmann,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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• Marija Cvijovic

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: marija.cvijovic@chalmers.se

  Affiliations Department of Mathematical Sciences, University of Gothenburg, Gothenburg, Sweden, Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden

  https://orcid.org/0000-0002-5142-5100

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