Predicting antimicrobial mechanism-of-action from transcriptomes: A generalizable explainable artificial intelligence approach

• Josh L. Espinoza ,

  Contributed equally to this work with: Josh L. Espinoza, Chris L. Dupont

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations J. Craig Venter Institute, La Jolla, CA, United States of America, Department of Applied Sciences, Durban University of Technology, Durban, South Africa

  https://orcid.org/0000-0003-3447-3845

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• Chris L. Dupont ,

  Contributed equally to this work with: Josh L. Espinoza, Chris L. Dupont

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: cdupont@jcvi.org

  Affiliation J. Craig Venter Institute, La Jolla, CA, United States of America

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• Aubrie O’Rourke,

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation J. Craig Venter Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0002-2890-1682

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• Sinem Beyhan,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation J. Craig Venter Institute, La Jolla, CA, United States of America

  https://orcid.org/0000-0003-0906-7538

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• Pavel Morales,

  Roles Investigation, Validation

  Affiliation J. Craig Venter Institute, La Jolla, CA, United States of America

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• Amy Spoering,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation

  Affiliation NovoBiotic Pharmaceuticals, Cambridge, MA, United States of America

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• Kirsten J. Meyer,

  Roles Writing – review & editing

  Affiliation Department of Biology, Northeastern University, Boston, MA, United States of America

  https://orcid.org/0000-0001-9487-7361

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• Agnes P. Chan,

  Roles Investigation

  Affiliation J. Craig Venter Institute, Rockville, MD, United States of America

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• Yongwook Choi,

  Roles Investigation

  Affiliation J. Craig Venter Institute, Rockville, MD, United States of America

  https://orcid.org/0000-0003-4017-9669

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• William C. Nierman,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation J. Craig Venter Institute, Rockville, MD, United States of America

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• Kim Lewis,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biology, Northeastern University, Boston, MA, United States of America

  https://orcid.org/0000-0002-1335-9982

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• Karen E. Nelson

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations J. Craig Venter Institute, La Jolla, CA, United States of America, Department of Applied Sciences, Durban University of Technology, Durban, South Africa, J. Craig Venter Institute, Rockville, MD, United States of America

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