Machine learning based CRISPR gRNA design for therapeutic exon skipping

• Wilson Louie,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0003-0194-5084

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• Max W. Shen,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation

  Affiliation Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-4226-1861

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• Zakir Tahiry,

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Sophia Zhang,

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-1494-8906

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• Daniel Worstell,

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-0632-1986

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• Christopher A. Cassa,

  Roles Conceptualization, Methodology, Validation

  Affiliation Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-5771-9177

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• Richard I. Sherwood ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: rsherwood@rics.bwh.harvard.edu (RIS); gifford@mit.edu (DKG)

  Affiliations Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Hubrecht Institute for Developmental Biology and Stem Cell Research, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, The Netherlands

  https://orcid.org/0000-0001-7427-7713

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• David K. Gifford

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rsherwood@rics.bwh.harvard.edu (RIS); gifford@mit.edu (DKG)

  Affiliations Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0003-1709-4034

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