Rosetta design with co-evolutionary information retains protein function

• Samuel Schmitz ,

  Contributed equally to this work with: Samuel Schmitz, Moritz Ertelt

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America

  https://orcid.org/0000-0001-5314-6095

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• Moritz Ertelt ,

  Contributed equally to this work with: Samuel Schmitz, Moritz Ertelt

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute for Drug Discovery, Leipzig University, Leipzig, Germany, Institute of Biophysics and Physical Biochemistry, University of Regensburg, Regensburg, Germany

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• Rainer Merkl,

  Roles Supervision, Writing – review & editing

  Affiliation Institute of Biophysics and Physical Biochemistry, University of Regensburg, Regensburg, Germany

  https://orcid.org/0000-0002-3521-2957

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• Jens Meiler

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: jens@meilerlab.org

  Affiliations Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America, Institute for Drug Discovery, Leipzig University, Leipzig, Germany

  https://orcid.org/0000-0001-8945-193X

  ⨯