Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1

• Milad Ghomlaghi ,

  Contributed equally to this work with: Milad Ghomlaghi, Guang Yang

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia, Biomedicine Discovery Institute, Monash University, Melbourne, Australia

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• Guang Yang ,

  Contributed equally to this work with: Milad Ghomlaghi, Guang Yang

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia

  https://orcid.org/0000-0003-4377-1836

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• Sung-Young Shin,

  Roles Formal analysis, Methodology, Supervision

  Affiliations Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia, Biomedicine Discovery Institute, Monash University, Melbourne, Australia

  https://orcid.org/0000-0002-1447-9687

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• David E. James,

  Roles Supervision

  Affiliation Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia

  https://orcid.org/0000-0001-5946-5257

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• Lan K. Nguyen

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Lan.K.Nguyen@monash.edu

  Affiliations Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia, Biomedicine Discovery Institute, Monash University, Melbourne, Australia

  https://orcid.org/0000-0003-4040-7705

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