Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness

• Ivan Carcamo-Orive ,

  Contributed equally to this work with: Ivan Carcamo-Orive, Marc Y. R. Henrion, Kuixi Zhu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ivantxo@stanford.edu (ICO); knowlej@stanford.edu (JWK); ruichang@email.arizona.edu (RC)

  Affiliation Stanford University School of Medicine, Division of Cardiovascular Medicine, Cardiovascular Institute, and Diabetes Research Center, Stanford, California, United States of America

  https://orcid.org/0000-0001-8823-4925

  ⨯
• Marc Y. R. Henrion ,

  Contributed equally to this work with: Ivan Carcamo-Orive, Marc Y. R. Henrion, Kuixi Zhu

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom, Malawi—Liverpool—Wellcome Trust Clinical Research Programme, Blantyre, Malawi

  https://orcid.org/0000-0003-1242-839X

  ⨯
• Kuixi Zhu ,

  Contributed equally to this work with: Ivan Carcamo-Orive, Marc Y. R. Henrion, Kuixi Zhu

  Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft

  Affiliations Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Neurology, University of Arizona, Tucson, Arizona, United States of America, The Center for Innovations in Brain Sciences, University of Arizona, Tucson, Arizona, United States of America

  https://orcid.org/0000-0003-4361-1138

  ⨯
• Noam D. Beckmann,

  Roles Formal analysis, Software

  Affiliation Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  ⨯
• Paige Cundiff,

  Roles Investigation, Validation

  Affiliation Vertex Pharmaceuticals, Boston, Massachusetts, United States of America

  ⨯
• Sara Moein,

  Roles Software, Writing – original draft

  Affiliations Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Neurology, University of Arizona, Tucson, Arizona, United States of America, The Center for Innovations in Brain Sciences, University of Arizona, Tucson, Arizona, United States of America

  ⨯
• Zenan Zhang,

  Roles Software

  Affiliation Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  ⨯
• Melissa Alamprese,

  Roles Software

  Affiliations Department of Neurology, University of Arizona, Tucson, Arizona, United States of America, The Center for Innovations in Brain Sciences, University of Arizona, Tucson, Arizona, United States of America

  https://orcid.org/0000-0002-5290-1789

  ⨯
• Sunita L. D’Souza,

  Roles Investigation

  Affiliation Department of Cellular, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  ⨯
• Martin Wabitsch,

  Roles Methodology

  Affiliation Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology, Ulm University, Ulm, Germany

  ⨯
• Eric E. Schadt,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  ⨯
• Thomas Quertermous,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Stanford University School of Medicine, Division of Cardiovascular Medicine, Cardiovascular Institute, and Diabetes Research Center, Stanford, California, United States of America

  https://orcid.org/0000-0002-7645-9067

  ⨯
• Joshua W. Knowles ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: ivantxo@stanford.edu (ICO); knowlej@stanford.edu (JWK); ruichang@email.arizona.edu (RC)

  ¶‡ senior author.

  Affiliation Stanford University School of Medicine, Division of Cardiovascular Medicine, Cardiovascular Institute, and Diabetes Research Center, Stanford, California, United States of America

  https://orcid.org/0000-0003-1922-7240

  ⨯
• Rui Chang

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: ivantxo@stanford.edu (ICO); knowlej@stanford.edu (JWK); ruichang@email.arizona.edu (RC)

  ¶‡ senior author.

  Affiliations Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Neurology, University of Arizona, Tucson, Arizona, United States of America, The Center for Innovations in Brain Sciences, University of Arizona, Tucson, Arizona, United States of America, INTelico Therapeutics LLC, Tucson, Arizona, United States of America

  ⨯