Integrating structure-based machine learning and co-evolution to investigate specificity in plant sesquiterpene synthases

Janani Durairaj; Elena Melillo; Harro J. Bouwmeester; Jules Beekwilder; Dick de Ridder; Aalt D. J. van Dijk

doi:10.1371/journal.pcbi.1008197

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Open Access

Peer-reviewed

Research Article

Integrating structure-based machine learning and co-evolution to investigate specificity in plant sesquiterpene synthases

Janani Durairaj ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft

* E-mail: janani.durairaj@wur.nl (JD); aaltjan.vandijk@wur.nl (ADJD)

Affiliation Bioinformatics Group, Department of Plant Sciences, Wageningen University and Research, Wageningen, The Netherlands

https://orcid.org/0000-0002-1698-4556

⨯
Elena Melillo,

Roles Investigation, Validation, Visualization, Writing – review & editing

Affiliation Isobionics, Geleen, The Netherlands
⨯
Harro J. Bouwmeester,

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands

https://orcid.org/0000-0003-0907-2732

⨯
Jules Beekwilder,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliations Bioscience, Wageningen Plant Research, Wageningen University and Research, Wageningen, The Netherlands, Laboratory of Plant Physiology, Department of Plant Sciences, Wageningen University and Research, Wageningen, The Netherlands

https://orcid.org/0000-0003-3238-4427

⨯
Dick de Ridder,

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Bioinformatics Group, Department of Plant Sciences, Wageningen University and Research, Wageningen, The Netherlands

https://orcid.org/0000-0002-4944-4310

⨯
Aalt D. J. van Dijk

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: janani.durairaj@wur.nl (JD); aaltjan.vandijk@wur.nl (ADJD)

Affiliations Bioinformatics Group, Department of Plant Sciences, Wageningen University and Research, Wageningen, The Netherlands, Biometris, Department of Plant Sciences, Wageningen University and Research, Wageningen, The Netherlands

https://orcid.org/0000-0002-8872-5123

⨯

Integrating structure-based machine learning and co-evolution to investigate specificity in plant sesquiterpene synthases

Janani Durairaj,
Elena Melillo,
Harro J. Bouwmeester,
Jules Beekwilder,
Dick de Ridder,
Aalt D. J. van Dijk

Published: March 22, 2021
https://doi.org/10.1371/journal.pcbi.1008197
See the preprint

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