Computer-guided binding mode identification and affinity improvement of an LRR protein binder without structure determination

• Yoonjoo Choi ,

  Contributed equally to this work with: Yoonjoo Choi, Sukyo Jeong

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea

  http://orcid.org/0000-0001-9687-8093

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• Sukyo Jeong ,

  Contributed equally to this work with: Yoonjoo Choi, Sukyo Jeong

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea

  http://orcid.org/0000-0001-5581-6355

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• Jung-Min Choi,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea

  http://orcid.org/0000-0003-2450-3916

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• Christian Ndong,

  Roles Data curation, Investigation, Resources, Validation

  Affiliation Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, United States of America

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• Karl E. Griswold,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, United States of America, Norris Cotton Cancer Center at Dartmouth, Lebanon, New Hampshire, United States of America, Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

  http://orcid.org/0000-0002-9835-3394

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• Chris Bailey-Kellogg,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Department of Computer Science, Dartmouth College, Hanover, New Hampshire, United States of America

  http://orcid.org/0000-0003-1860-0912

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• Hak-Sung Kim

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: hskim76@kaist.ac.kr

  Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea

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