Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits

• Craig A. Glastonbury ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: craig.glastonbury@benevolent.ai (CAG); celi@bdi.ox.ac.uk (CML)

  ¶‡ CAG, SLP, and JH share first authorship on this work. TMF, MC, and CML are joint senior authors on this work.

  Affiliations Big Data Institute, University of Oxford, Oxford, United Kingdom, BenevolentAI, London, United Kingdom

  http://orcid.org/0000-0001-5542-2225

  ⨯
• Sara L. Pulit ,

  Roles Formal analysis, Visualization, Writing – review & editing

  ¶‡ CAG, SLP, and JH share first authorship on this work. TMF, MC, and CML are joint senior authors on this work.

  Affiliation Big Data Institute, University of Oxford, Oxford, United Kingdom

  ⨯
• Julius Honecker ,

  Roles Formal analysis, Validation, Writing – review & editing

  ¶‡ CAG, SLP, and JH share first authorship on this work. TMF, MC, and CML are joint senior authors on this work.

  Affiliation Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany

  http://orcid.org/0000-0002-1592-7023

  ⨯
• Jenny C. Censin,

  Roles Validation

  Affiliations Big Data Institute, University of Oxford, Oxford, United Kingdom, Wellcome Centre for Human Genetics (WCHG), Oxford, United Kingdom

  http://orcid.org/0000-0001-6625-6074

  ⨯
• Samantha Laber,

  Roles Data curation

  Affiliations Big Data Institute, University of Oxford, Oxford, United Kingdom, Broad Institute of MIT and Harvard, Cambridge Massachusetts, United States of America

  ⨯
• Hanieh Yaghootkar,

  Roles Validation

  Affiliations Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom, Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, United Kingdom

  http://orcid.org/0000-0001-9672-9477

  ⨯
• Nilufer Rahmioglu,

  Roles Validation

  Affiliations Wellcome Centre for Human Genetics (WCHG), Oxford, United Kingdom, Endometriosis CaRe Centre Oxford, Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, United Kingdom

  http://orcid.org/0000-0002-5169-8571

  ⨯
• Emilie Pastel,

  Roles Data curation

  Affiliation Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom

  ⨯
• Katerina Kos,

  Roles Validation

  Affiliation Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom

  http://orcid.org/0000-0003-3761-2249

  ⨯
• Andrew Pitt,

  Roles Validation

  Affiliation NIHR Exeter Clinical Research Facility, University of Exeter Medical School, University of Exeter and Royal Devon and Exeter NHS Foundation Trust Exeter, United Kingdom

  http://orcid.org/0000-0002-0721-2466

  ⨯
• Michelle Hudson,

  Roles Validation

  Affiliation NIHR Exeter Clinical Research Facility, University of Exeter Medical School, University of Exeter and Royal Devon and Exeter NHS Foundation Trust Exeter, United Kingdom

  http://orcid.org/0000-0003-0623-1873

  ⨯
• Christoffer Nellåker,

  Roles Supervision

  Affiliations Big Data Institute, University of Oxford, Oxford, United Kingdom, Endometriosis CaRe Centre Oxford, Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, United Kingdom

  http://orcid.org/0000-0002-2887-2068

  ⨯
• Nicola L. Beer,

  Roles Project administration

  Affiliation Novo Nordisk Research Centre Oxford (NNRCO), Oxford, United Kingdom

  ⨯
• Hans Hauner,

  Roles Validation

  Affiliations Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany, Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, German Center of Diabetes Research, Helmholtz Center Munich, Neuherberg, Germany

  http://orcid.org/0000-0002-1682-5088

  ⨯
• Christian M. Becker,

  Roles Validation

  Affiliation Endometriosis CaRe Centre Oxford, Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, United Kingdom

  http://orcid.org/0000-0002-9870-9581

  ⨯
• Krina T. Zondervan,

  Roles Validation

  Affiliations Wellcome Centre for Human Genetics (WCHG), Oxford, United Kingdom, Endometriosis CaRe Centre Oxford, Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, United Kingdom

  http://orcid.org/0000-0002-0275-9905

  ⨯
• Timothy M. Frayling ,

  Roles Resources, Validation

  ¶‡ CAG, SLP, and JH share first authorship on this work. TMF, MC, and CML are joint senior authors on this work.

  Affiliations Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, University of Exeter and Royal Devon and Exeter NHS Foundation Trust Exeter, United Kingdom

  http://orcid.org/0000-0001-8362-2603

  ⨯
• Melina Claussnitzer ,

  Roles Validation

  ¶‡ CAG, SLP, and JH share first authorship on this work. TMF, MC, and CML are joint senior authors on this work.

  Affiliations Broad Institute of MIT and Harvard, Cambridge Massachusetts, United States of America, University of Hohenheim, Stuttgart, Germany, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
•  [ ... ],
• Cecilia M. Lindgren

  Roles Funding acquisition, Supervision, Writing – review & editing

  * E-mail: craig.glastonbury@benevolent.ai (CAG); celi@bdi.ox.ac.uk (CML)

  ¶‡ CAG, SLP, and JH share first authorship on this work. TMF, MC, and CML are joint senior authors on this work.

  Affiliations Big Data Institute, University of Oxford, Oxford, United Kingdom, Wellcome Centre for Human Genetics (WCHG), Oxford, United Kingdom, Broad Institute of MIT and Harvard, Cambridge Massachusetts, United States of America

  http://orcid.org/0000-0002-4903-9374

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