Combining hypoxia-activated prodrugs and radiotherapy in silico: Impact of treatment scheduling and the intra-tumoural oxygen landscape

• Sara Hamis,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations School of Mathematics and Statistics, University of St Andrews, St Andrews, Scotland, Department of Mathematics, College of Science, Swansea University, Swansea, Wales, United Kingdom

  http://orcid.org/0000-0002-1105-8078

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• Mohammad Kohandel,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Department of Applied Mathematics, University of Waterloo, Waterloo, Canada

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• Ludwig J. Dubois,

  Roles Conceptualization, Writing – review & editing

  Affiliation The M-Lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  http://orcid.org/0000-0002-8887-4137

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• Ala Yaromina,

  Roles Conceptualization, Writing – review & editing

  Affiliation The M-Lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

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• Philippe Lambin,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation The M-Lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands

  http://orcid.org/0000-0001-7961-0191

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• Gibin G. Powathil

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: g.g.powathil@swansea.ac.uk

  Affiliation Department of Mathematics, College of Science, Swansea University, Swansea, Wales, United Kingdom

  http://orcid.org/0000-0002-8372-7349

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