Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications

Martín Carballo-Pacheco; Michael D. Nicholson; Elin E. Lilja; Rosalind J. Allen; Bartlomiej Waclaw

doi:10.1371/journal.pcbi.1007930

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Peer-reviewed

Research Article

Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications

Martín Carballo-Pacheco ,

Contributed equally to this work with: Martín Carballo-Pacheco, Michael D. Nicholson

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Michael D. Nicholson ,

Contributed equally to this work with: Martín Carballo-Pacheco, Michael D. Nicholson

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

http://orcid.org/0000-0003-2813-8979

⨯
Elin E. Lilja,

Roles Conceptualization, Writing – review & editing

Affiliation School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Rosalind J. Allen,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom, Centre for Synthetic and Systems Biology, The University of Edinburgh, Edinburgh, United Kingdom

http://orcid.org/0000-0003-4110-2962

⨯
Bartlomiej Waclaw

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: bwaclaw@staffmail.ed.ac.uk

Affiliations School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom, Centre for Synthetic and Systems Biology, The University of Edinburgh, Edinburgh, United Kingdom

http://orcid.org/0000-0001-5355-7994

⨯

Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications

Martín Carballo-Pacheco,
Michael D. Nicholson,
Elin E. Lilja,
Rosalind J. Allen,
Bartlomiej Waclaw

Published: May 29, 2020
https://doi.org/10.1371/journal.pcbi.1007930

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